diff --git a/src/PhpSpreadsheet/Worksheet/PageSetup.php b/src/PhpSpreadsheet/Worksheet/PageSetup.php
index d8d5098f..d1a22a7b 100644
--- a/src/PhpSpreadsheet/Worksheet/PageSetup.php
+++ b/src/PhpSpreadsheet/Worksheet/PageSetup.php
@@ -678,6 +678,9 @@ class PageSetup
             throw new PhpSpreadsheetException('Cell coordinate must not be absolute.');
         }
         $value = strtoupper($value);
+        if (!$this->printArea) {
+            $index = 0;
+        }
 
         if ($method == self::SETPRINTRANGE_OVERWRITE) {
             if ($index == 0) {
@@ -695,7 +698,7 @@ class PageSetup
             }
         } elseif ($method == self::SETPRINTRANGE_INSERT) {
             if ($index == 0) {
-                $this->printArea .= ($this->printArea == '') ? $value : ',' . $value;
+                $this->printArea = $this->printArea ? ($this->printArea . ',' . $value) : $value;
             } else {
                 $printAreas = explode(',', $this->printArea);
                 if ($index < 0) {
diff --git a/tests/PhpSpreadsheetTests/Functional/PrintAreaTest.php b/tests/PhpSpreadsheetTests/Functional/PrintAreaTest.php
index a335fd2f..584f6dd5 100644
--- a/tests/PhpSpreadsheetTests/Functional/PrintAreaTest.php
+++ b/tests/PhpSpreadsheetTests/Functional/PrintAreaTest.php
@@ -22,7 +22,7 @@ class PrintAreaTest extends AbstractFunctional
      */
     public function testPageSetup($format): void
     {
-        // Create new workbook with 3 sheets and different print areas
+        // Create new workbook with 6 sheets and different print areas
         $spreadsheet = new Spreadsheet();
         $worksheet1 = $spreadsheet->getActiveSheet()->setTitle('Sheet 1');
         $worksheet1->getPageSetup()->setPrintArea('A1:B1');
@@ -34,16 +34,25 @@ class PrintAreaTest extends AbstractFunctional
 
         $worksheet4 = $spreadsheet->createSheet()->setTitle('Sheet 4');
         $worksheet4->getPageSetup()->setPrintArea('A4:B4,D1:E4');
+        $worksheet5 = $spreadsheet->createSheet()->setTitle('Sheet 5');
+        $worksheet5->getPageSetup()->addPrintAreaByColumnAndRow(1, 1, 10, 10, 1);
+        $worksheet6 = $spreadsheet->createSheet()->setTitle('Sheet 6');
+        $worksheet6->getPageSetup()->addPrintAreaByColumnAndRow(1, 1, 10, 10, 1);
+        $worksheet6->getPageSetup()->addPrintAreaByColumnAndRow(12, 1, 12, 10, 1);
 
         $reloadedSpreadsheet = $this->writeAndReload($spreadsheet, $format, function (BaseReader $reader): void {
-            $reader->setLoadSheetsOnly(['Sheet 1', 'Sheet 3', 'Sheet 4']);
+            $reader->setLoadSheetsOnly(['Sheet 1', 'Sheet 3', 'Sheet 4', 'Sheet 5', 'Sheet 6']);
         });
 
         $actual1 = $reloadedSpreadsheet->getSheetByName('Sheet 1')->getPageSetup()->getPrintArea();
         $actual3 = $reloadedSpreadsheet->getSheetByName('Sheet 3')->getPageSetup()->getPrintArea();
         $actual4 = $reloadedSpreadsheet->getSheetByName('Sheet 4')->getPageSetup()->getPrintArea();
+        $actual5 = $reloadedSpreadsheet->getSheetByName('Sheet 5')->getPageSetup()->getPrintArea();
+        $actual6 = $reloadedSpreadsheet->getSheetByName('Sheet 6')->getPageSetup()->getPrintArea();
         self::assertSame('A1:B1', $actual1, 'should be able to write and read normal page setup');
         self::assertSame('A3:B3', $actual3, 'should be able to write and read page setup even when skipping sheets');
         self::assertSame('A4:B4,D1:E4', $actual4, 'should be able to write and read page setup with multiple print areas');
+        self::assertSame('A1:J10', $actual5, 'add by column and row');
+        self::assertSame('A1:J10,L1:L10', $actual6, 'multiple add by column and row');
     }
 }